Interferon Alpha Treatment and Thyroid Dysfunction
نویسندگان
چکیده
منابع مشابه
Thyroid dysfunction in hepatitis C individuals treated with interferon-alpha and ribavirin--a review.
Hepatitis C (HCV) is now the main cause of chronic hepatic disease, cirrhosis and hepatocellular carcinoma. Several extrahepatic diseases have been associated with chronic HCV infection, and in most cases appear to be directly related to the viral infection. Thyroid disorders are common in patients with chronic HCV. Some patients with chronic hepatitis C experience thyroid problems, and thyroid...
متن کاملInterferon-Alpha Induced and Ribavirin Induced Thyroid Dysfunction in Patients with Chronic Hepatitis C
Chronic hepatitis C (CHC) is one of the commonest infectious diseases of the liver and may lead to cirrhosis or hepatocellular carcinoma. Combination therapy with pegylated interferon (PEG-IFN) and Ribavirin is the treatment of choice for CHC. Combination therapy is thought to act by means of antiviral mechanisms and immunomodulation. Thyroid dysfunction is the most common autoimmune adverse ef...
متن کاملVirologic factors related to interferon-alpha-induced thyroid dysfunction in patients with chronic hepatitis C.
OBJECTIVE Hepatitis C virus (HCV), being reported to be associated with a high prevalence of serological markers of autoimmunity in HCV-infected patients, and possibly sharing partial sequences in amino acid segments with thyroid tissue antigens, may be associated with interferon-alpha (IFN-alpha)-induced thyroid dysfunction in chronic hepatitis C patients. We conducted this study to clarify th...
متن کاملThyroid hormonal disturbances related to treatment of hepatitis C with interferon-alpha and ribavirin
OBJECTIVE To characterize thyroid disturbances induced by interferon-alpha and ribavirin therapy in patients with chronic hepatitis C. INTRODUCTION Interferon-alpha is used to treat chronic hepatitis C infections. This compound commonly induces both autoimmune and non-autoimmune thyroiditis. METHODS We prospectively selected 26 patients with chronic hepatitis C infections. Clinical examinat...
متن کاملTreatment Modalities in Thyroid Dysfunction
Thyroid dysfunction is a common condition mainly affecting women, with a male to female ratio of around 1:10. An organ-specific autoimmune response is the underlying cause in the majority and susceptibility to thyroid autoimmunity is believed to be influenced by an interaction between genetic predisposition and environmental factors, in addition to endogenous factors such as age and sex (Vander...
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ژورنال
عنوان ژورنال: Endocrinology and Metabolism Clinics of North America
سال: 2007
ISSN: 0889-8529
DOI: 10.1016/j.ecl.2007.07.001